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Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir Article

Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fen-Er Chen

Engineering 2023, Volume 21, Issue 2,   Pages 92-100 doi: 10.1016/j.eng.2021.07.029

Abstract: antiviral drug remdesivir, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, was synthesized through five-step continuousThe salient feature of this synthesis is that the workup procedures are fully integrated into the reactionsequences by deploying dedicated equipment and separation units, thus forming a streamlined continuous-flow

Keywords： Flow chemistry     Continuous multistep synthesis     Microreaction technology     Reaction–separation integration    

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Automated synthesis of steady-state continuous processes using reinforcement learning

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 288-302 doi: 10.1007/s11705-021-2055-9

Abstract: Automated flowsheet synthesis is an important field in computer-aided process engineering.The present work demonstrates how reinforcement learning can be used for automated flowsheet synthesisTherein, flowsheet synthesis is modelled as a game of two competing players.

Keywords： automated process synthesis     flowsheet synthesis     artificial intelligence     machine learning     reinforcement    

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An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1 Article

Meifen Jiang, Minjie Liu, Weijian Li, Yingqi Xia, Fener Chen

Engineering 2024, Volume 32, Issue 1,   Pages 230-239 doi: 10.1016/j.eng.2023.01.016

Abstract: This study reports on an integrated eight-step continuous-flow synthesis of vitamin B1 fromThe proposed continuous-flow process is based on advances in chemistry, engineering, and equipment designthe prevention of side reactions, using various micro-channel flow reactors, mixers, separators, and continuousThis eight-step continuous-flow protocol enables technology involving up to six of the key principles

Keywords： Vitamin B1     Continuous-flow synthesis     Micro-reactor     Continuous manufacturing    

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Microfluidic dual loops reactor for conducting a multistep reaction

Si Hyung Jin, Jae-Hoon Jung, Seong-Geun Jeong, Jongmin Kim, Tae Jung Park, Chang-Soo Lee

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2,   Pages 239-246 doi: 10.1007/s11705-017-1680-9

Abstract: Precise control of each individual reaction that constitutes a multistep reaction must be performed toIn this work, we present a microfluidic dual loops reactor that enables multistep reaction by integratingloops reactor is integrated with several valves to realize the fully automated unit operation of a multistepnanoparticles are successfully synthesized in a microfluidic dual loops reactor through a fully automated multistepreactor is a general microfluidic screening platform that can synthesize various materials through a multistep

Keywords： microfluidics     multistep reaction     rotary mixing     nanoparticle    

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Multistep conversion of cresols by phenol hydroxylase and 2,3-dihydroxy-biphenyl 1,2-dioxygenase

Shengnan SHI,Fang MA,Tieheng SUN,Ang LI,Jiti ZHOU,Yuanyuan QU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 4,   Pages 539-546 doi: 10.1007/s11783-013-0616-y

Abstract: A multistep conversion system composed of phenol hydroxylase (PH ) and 2,3-dihydroxy-biphenyl 1,2-dioxygenasedisplayed by PyMOL predicted that cresols and methylcatechols could be theoretically transformed by this multistepliquid chromatography mass spectrometry (HPLC-MS) analysis also indicated that the products formed from multistepexpressing phenol hydroxylase (PH ) and 2,3-dihydroxy-biphenyl 1,2-dioxygenase (BphC ) and pH for the multistepThe present study suggested the potential application of the multistep conversion system for the production

Keywords： multistep conversion     cresols     phenol hydroxylase     2     3-dihydroxybiphenyl 1     2-dioxygenase     methylcatechols    

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Strain and process engineering toward continuous industrial fermentation

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1336-1353 doi: 10.1007/s11705-022-2284-6

Abstract: To increase the economic competitiveness of biological processes, continuous fermentation technologiesHowever, several key challenges should be addressed for the industrial application of continuous fermentation

Keywords： continuous fermentation     productivity     contamination     strain degeneration     metabolic engineering    

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Ant colony optimization in continuous problem

YU Ling, LIU Kang, LI Kaishi

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 4,   Pages 459-462 doi: 10.1007/s11465-007-0079-6

Abstract: Based on the analysis of the basic ant colony optimization and optimum problem in a continuous space,an ant colony optimization (ACO) for continuous problem is constructed and discussed.The algorithm is efficient and beneficial to the study of the ant colony optimization in a continuous

Keywords： beneficial     algorithm     efficient     continuous     ACO    

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Industrialization of the Advanced Technology in Continuous Casting of Steel

Gan Yong

Strategic Study of CAE 2002, Volume 4, Issue 9,   Pages 12-18

Abstract:

The characteristics of key technology in high-effective and thin-slab continuous casting of steeltechnologies such as soft reduction, hydraulic-driven non-sinusoidal oscillation, and electromagnetic continuousThe progress direction of high-efficiency and high quality of conventional continuous casting is discussed, and the development trend of near-net-shape continuous casting and electromagnetic continuous casing

Keywords： continuous casting of steel     high-effective continuous casting     thin slab continuous casting     soft reduction     electromagnetic continuous casting     industrialization    

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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1866-1878 doi: 10.1007/s11705-023-2340-x

Abstract: Continuous glucose monitoring (CGM) systems play an increasingly vital role in the glycemic control of

Keywords： implantable glucose biosensor     anti-biofouling     continuous glucose monitoring     immune responses    

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Bending and rotational behaviour of semi-continuous composite beams

WANG Jingfeng, LI Guoqiang

Frontiers of Structural and Civil Engineering 2008, Volume 2, Issue 2,   Pages 116-122 doi: 10.1007/s11709-008-0015-9

Abstract: Stresses and deflections were measured in various semi-continuous composite beams.The tests show that the semi-continuous composite beams are more economic and effective than the simpleor continuous composite beams.

Keywords： rotational     effective     deflection calculation     semi-continuous composite     full-scale semi-rigid    

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Seismic performance of fabricated continuous girder bridge with grouting sleeve-prestressed tendon composite

Frontiers of Structural and Civil Engineering   Pages 827-854 doi: 10.1007/s11709-023-0954-1

Abstract: A numerical analysis of three types of continuous girder bridges was conducted with different piers:

Keywords： seismic performance     continuous girder bridge     grouting sleeve-prestressed tendon composite connections    

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Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 68-74 doi: 10.1007/s11684-022-0955-9

Abstract: new parameter for continuously evaluating personal clinical statuses, the newly developed technique “continuous

Keywords： complexity of glucose time series     continuous glucose monitoring     impaired glucose regulation     insulin    

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Analysis of load transfer stability control strategy in hydraulic synchronized continuous slippage

LIU Yan-bo, WU Jian-zhong, ZHANG Xuan

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 2,   Pages 222-226 doi: 10.1007/s11465-006-0007-1

Abstract: Hydraulic synchronized continuous slippage technique, which integrates mechanical, electrical and hydraulic

Keywords： excessive     slippage technique     optimization     continuous slippage     engineering    

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Non-invasive continuous blood pressure monitoring: a review of current applications

Elena Chung, Guo Chen, Brenton Alexander, Maxime Cannesson

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 91-101 doi: 10.1007/s11684-013-0239-5

Abstract: limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuousblood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous

Keywords： non-invasive blood pressure monitoring     continuous blood pressure monitoring     invasive blood pressure monitoring    

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Removal of dyes from wastewater by growing fungal pellets in a semi-continuous mode

Tao Lu, Qilei Zhang, Shanjing Yao

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 3,   Pages 338-345 doi: 10.1007/s11705-017-1644-0

Abstract: This semi-continuous mode, which consists of commutative processes of dye-removal and re-culture, has

Keywords： dye     mycelial pellets     marine fungus     bubble column reactor     semi-continuous biosorption    

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Title Author Date Type Operation

Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir

Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fen-Er Chen

Journal Article

Automated synthesis of steady-state continuous processes using reinforcement learning

Journal Article

An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1

Meifen Jiang, Minjie Liu, Weijian Li, Yingqi Xia, Fener Chen

Journal Article

Microfluidic dual loops reactor for conducting a multistep reaction

Si Hyung Jin, Jae-Hoon Jung, Seong-Geun Jeong, Jongmin Kim, Tae Jung Park, Chang-Soo Lee

Journal Article

Multistep conversion of cresols by phenol hydroxylase and 2,3-dihydroxy-biphenyl 1,2-dioxygenase

Shengnan SHI,Fang MA,Tieheng SUN,Ang LI,Jiti ZHOU,Yuanyuan QU

Journal Article

Strain and process engineering toward continuous industrial fermentation

Journal Article

Ant colony optimization in continuous problem

YU Ling, LIU Kang, LI Kaishi

Journal Article

Industrialization of the Advanced Technology in Continuous Casting of Steel

Gan Yong

Journal Article

Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Journal Article

Bending and rotational behaviour of semi-continuous composite beams

WANG Jingfeng, LI Guoqiang

Journal Article

Seismic performance of fabricated continuous girder bridge with grouting sleeve-prestressed tendon composite

Journal Article

Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated

Journal Article

Analysis of load transfer stability control strategy in hydraulic synchronized continuous slippage

LIU Yan-bo, WU Jian-zhong, ZHANG Xuan

Journal Article

Non-invasive continuous blood pressure monitoring: a review of current applications

Elena Chung, Guo Chen, Brenton Alexander, Maxime Cannesson

Journal Article

Removal of dyes from wastewater by growing fungal pellets in a semi-continuous mode

Tao Lu, Qilei Zhang, Shanjing Yao

Journal Article